For what it’s worth, I regularly print materials not supported by the AMS on my Bambu P1S and it’s quite painless. There’s a spool holder on the back of the machine that you can load directly to the extruder bypassing the AMS. Of course, if your goal is do multicolor prints in TPU obviously that won’t work.

Yeah Proton is definitely the way to go over using Wine directly. Valve has put a ton of work into making it seamless. I have a large steam library and have found literally only one game (Destiny 2) that doesn’t work. And that’s just because Bungie has gone out of their way to make sure it won’t run on Linux for “anti cheating” reasons.