Hmm I’m using it on Bazzite with KDE, which is based off Fedora 42 atomic. I haven’t really noticed any issues with it, though I haven’t printed anything in awhile

I use PrusaSlicer from Flathub. I was using PrusaSlicer on Windows before switching to Linux. I’ve been using it since the original Slic3r stopped getting updates. Because it’s available as a flatpak it should work on pretty much any distro and immutable distros