Depending on how power hungry the drives are, and if your PSU has enough spare power, you can get cable splitters. I had some spare molex ports which I plugged a cable from Amazon that split it into 5 SATA power connectors.

You don’t want to infinitely split cables though, as tempting as that can be, because there are real electrical limits to doing that. Also just because a power supply is rated at X watts, that’s the total. Hard drives will use the 5V and 12V rails and usually there are individual limits on each rail.

Upgrading the PSU is another option. Probably the cleanest easiest best solution IMO. But even then, you probably can’t find a PSU that’ll give you 12 SATA connectors out of the box so you’ll probably need some splitters in there anyways.

In my case specifically, I’ve actually got a second power supply (because i already had it and it was otherwise just gathering dust) powering the extra drives. It’s a bit more complicated to get set up but, it’s an option as well.

Edit: also if you’re asking yourself where can you physically PUT the drives, I 3D printed these and slapped some fans on them:

https://www.thingiverse.com/thing:4875498

What value is there you knowing my expression of ARHGAP1? What about TP53BP1?

Yeah, or someone will die because lab result baselines that are dependent on sex get fucked up.

Politics need to stay the fuck out of medicine. Having people try and do a political dance around lab science is a recipe for disaster.

As others have said, running out of motherboard SATA slots doesn’t mean you need a new machine to support expansion.

You can get m2 adapter slots for more SATA drives.

If you think you’ll be building a NAS in the future, and are cheap like I am, you might consider getting a pci-e expansion card for SAS rather than SATA drives. They’re backwards compatibile with SATA drives, but open you up to being able to use SAS drives which are common in enterprise data centers. You can get used lots of those drives on eBay WAY cheaper per TB when the data centers hour them out.

I’ve got a machine with 16 SAS drives running the unRaid OS, and I’m very happy with it for data hoarding and media serving. The drives (with shipping) cost $5/TB.